Power tends to isolate those who hold too much of it. Eventually they lose touch with reality… and fall.

Sad? Nonsense! Parting with friends is a sadness. A place is only a place.” He glanced at the charts on the table. “And Arrakis is just another place.

How the mind gears itself for its environment, she thought. And she recalled a Bene Gesserit axiom: “The mind can go either direction under stress — toward positive or toward negative: on or off. Think of it as a spectrum whose extremes are unconsciousness at the negative end and hyperconsciousness at the positive end. The way the mind will lean under stress is strongly influenced by training.