THERAPEUTIC #2: METFORMIN — THE LOW-RISK WONDER DRUG “Metformin may have already saved more people from cancer deaths than any drug in history.”12 — LEWIS CANTLEY, director of the Meyer Cancer Center at Weill Cornell Medical College Now let’s take a look at another amazing medicine, one that our friend Dr. David Sinclair and millions of other people utilize every day… metformin. The FDA-approved, first-line treatment for type 2 diabetes, metformin, is wildly popular in the longevity field. My coauthors Bob Hariri and Peter Diamandis have been taking it for years. So have futurist-par-excellence Ray Kurzweil and biotech entrepreneur Ned David. And so does Nobel Prize winner James Watson of double-helix fame, who once went so far as to say that metformin might be “our only real clue into the business” of beating cancer. When a recent anti-aging forum of 300 people was asked who was using this medicine to extend their healthspan, half the audience raised their hands. As David Sinclair says, metformin “might work on aging itself.”13
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The first solution, according to Dr. David Sinclair and other top scientists in the age reversal space, lies in NAD+ supplements. Sinclair’s supplement of choice is nicotinamide mononucleotide (NMN).
If a medication could slash Alzheimer’s risk by 50 percent, it would be front-page news and prescribed to every patient. But this “drug” does exist — it’s walking! Yet less than 16 percent of doctors prescribe movement to their patients, and 85 percent of practitioners report zero training in prescribing exercise.
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View PlansIt would not all be easy sailing from here on, but modern pharmacological medicine gave my father ten extra years of life and a peace he might never have had. He and my mother got to celebrate their fiftieth wedding anniversary. He got to know his grandchildren and we became much closer. He became easier to reach, to know and love.
Vitamin D3 boasts a strong safety profile, along with broad and deep evidence that links it to brain, metabolic, cardiovascular, muscle, bone, lung, and immune health. New and emerging research suggests that vitamin D supplements may also slow down our epigenetic/biological aging.29, 30 2. Omega-3 fish oil: Over the last thirty years or so, the typical Western diet has added more and more pro-inflammatory omega-6 polyunsaturated fatty acids versus anti-inflammatory omega-3 PUFAs. Over the same period, we’ve seen an associated rise in chronic inflammatory diseases, including obesity, cardiovascular disease, rheumatoid arthritis, and Alzheimer’s disease. 31 Rich in omega-3s, fish oil is another incredibly versatile nutraceutical tool with multi-pronged benefits from head to toe. By restoring a healthier PUFA ratio, it especially helps your brain and heart. Regular consumption of fatty fish like salmon has been linked to a lower risk of congestive heart failure, coronary heart disease, sudden cardiac death, and stroke.32 In an observational study, omega-3 fish oil supplementation was also associated with a slower biological clock.33 3. Magnesium deficiency affects more than 45 percent of the U.S. population. Supplements can help us maintain brain and cardiovascular health, normal blood pressure, and healthy blood sugar metabolism. They may also reduce inflammation and help activate our vitamin D. 4. Vitamin K1/K2 supports blood clotting, heart/ blood vessel health, and bone health.34 5. Choline supplements with brain bioavailability, such as CDP-Choline, citicoline, or alpha-GPC, can boost your body’s storehouse of the neurotransmitter acetylcholine and possibly support liver and brain function, while protecting it from age-related insults.35 6. Creatine: This one may surprise you, since it’s often associated with serious athletes and fitness buffs. But according to Dr. Lopez, it’s “a bona fide arrow in my longevity nutraceutical quiver for most individuals, and especi
Life expectancy has increased primarily because of sanitation practices and infectious disease mitigation measures; because of emergency surgery techniques for acute and life-threatening conditions, like an inflamed appendix or trauma; and because of antibiotics to reverse life-threatening infections. In short, almost every “health miracle” we can point to is a cure for an acute issue (i.e., a problem that would kill you imminently if left unresolved). Economically, acute conditions aren’t great in our modern system, because the patient is quickly cured and no longer a customer. Starting in the 1960s, the medical system has taken the trust engendered by these acute innovations and used it to ask patients not to question its authority on chronic diseases (which can last a lifetime and thus are more profitable).
There's a cure for aging that no one talks about. It's called learning.
McCullough observes that, “We could have dramatically reduced COVID fatalities and hospitalizations using early treatment protocols and repurposed drugs including ivermectin and hydroxychloroquine and many, many others.” Dr. McCullough has treated some 2,000 COVID patients with these therapies. McCullough points out that hundreds of peer-reviewed studies now show that early treatment could have averted some 80 percent of deaths attributed to COVID. “The strategy from the outset should have been implementing protocols to stop hospitalizations through early treatment of Americans who tested positive for COVID but were still asymptomatic. If we had done that, we could have pushed case fatality rates below those we see with seasonal flu, and ended the bottlenecks in our hospitals. We should have rapidly deployed off-the-shelf medications with proven safety records and subjected them to rigorous risk/benefit decision-making,” McCullough continues. “Using repurposed drugs, we could have ended this pandemic by May 2020 and saved 500,000 American lives, but for Dr. Fauci’s hard-headed, tunnel vision on new vaccines and remdesivir.
Walking is man's best medicine.
Love is the most transformative medicine For Love slowly transforms you Into what psychedelics only get you to glimpse.
Here is the roadmap for the chapter ahead. We’ll be diving into what we consider the five key therapeutic areas that you can focus on, today, to increase your energy and vitality: 1. Peptides 2. Metformin 3. Hormone optimization therapy (HOT) 4. NAD+ precursors 5. Key nutraceuticals
The result: those who saw a palliative care specialist stopped chemotherapy sooner, entered hospice far earlier, experienced less suffering at the end of their lives — and they lived 25 percent longer. In other words, our decision making in medicine has failed so spectacularly that we have reached the point of actively inflicting harm on patients rather than confronting the subject of mortality. If end-of-life discussions were an experimental drug, the FDA would approve it.
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View Plansend-of-life discussions were an experimental drug, the FDA would approve it.
The greatest cure for love is still that time honoured medicine - love returned.
Work, he said, was a first-rate medicine for any illness.
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