To lose the only creature in all his world who ever had manifested love and affection for him was the greatest tragedy he had ever known.

This is the saddest story I have ever heard.

a friend of your youth is the only friend you ever have..

The greatest tragedy in life is not death but life without a purpose — life with the wrong priorities. Life’s greatest challenge is in knowing what to do. The greatest mistake in life is to be busy but not effective. Life’s greatest failure is to be successful in the wrong assignment. Success in life is measured by the effective use of one’s time.

the biggest tragedy of life is the utter impossibility to change what you have done

The only thing worse than being a disaster is being a disaster with a witness.

The greatest tragedy of the family is the unlived lives of the parents.

-did you think of her as your best friend?
-she was my only friend.
-your best and only.
-my one and only. if you have only one of something you can't say it's the best of anything.

Your sister is the only true friend you'll ever have.

Monotheism is easily the greatest disaster to befall the human race.

A tragedy is a representation of an action that is whole and complete and of a certain magnitude. A whole is what has a beginning and middle and end.

greatest tragedy in life is not death, but a life that never realized its full potential.

There's no greater misfortune than dying alone.

The greatest tragedy in mankind's entire history may be the hijacking of morality by religion