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When one is concerned with the mysterious and wonderful functioning of the human body, cause and effect are seldom simple and easily demonstrated relationships. They may be widely separated both in space and time. To discover the agent of disease and death depends on a patient piecing together of many seemingly distinct and unrelated facts developed through a vast amount of research in widely separated fields.

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[...} many things must remain uncertain, and many a question insoluble, because what we know of nature is by no means sufficient, in all cases, to explain what has to be explained.

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