TO REDUCE APPETITE, PROMOTE FAT LOSS, AND REBALANCE OUR METABOLISM: The peptide semaglutide (and other glucagon-like peptide-1 agonists) have aced four-year-plus clinical trials, with subjects routinely losing 15 percent of their body weight — or 30 pounds for someone weighing in at 200. Generally well-tolerated, with a terrific safety profile, GLP-1s can be game-changers when added to a healthy diet, exercise, and other lifestyle changes. Occasional side effects: nausea, diarrhea, and flatulence. May not be suitable for individuals with a history of thyroid gland tumors. MOTS-c and Humanin are derived from the mitochondria, our cells’ power packs. Among other things, they may revitalize our carbohydrate and fat metabolism. This category of mitochondrial peptides is a potential wellspring of future innovation for longevity, healthspan, and peak performance!

TO REVIVE OUR SKIN AND RESTORE OUR HAIR: The peptide GHK-Cu is a topical foam that can be used daily to erase fine lines and wrinkles. It counteracts cosmetic aging by boosting collagen synthesis up to 70 percent.10 According to Dr. William Seeds, chairman of the International Peptide Society, GHK-Cu also stimulates wound healing and “amazing” hair growth.

STEP THREE: MAXIMIZE YOUR ENERGY & REGENERATION Consider what aspects of Vitality Pharmacy (Chapter 10) might help you accelerate your energy, your strength, your vitality. Or help you to recover from challenges you may be facing. 1. Are you going to expand your capacity by optimizing your hormones through H.O.T. (hormone optimization therapy)? 2. Would peptides be something you may want to consider? Are there any peptides that you’d like to look into that could make a difference in anything from your immune system to sexual desire and drive? 3. What are some of the pharmaceutical-grade supplements that you might want to have to start your day with energy or to get yourself to sleep at night without side effects? 4. Or would you like to tap into NAD3 or other NMN-like products to maximize your energy and vitality?

Huang was skeptical when his doctors told him there was a new drug option called semaglutide (sold under the brand name Ozempic). The doctor had seen some astounding results from this new drug, including a 50 percent drop in HbA1c levels and a weight loss of as much as 50 pounds. What’s more, these dramatic improvements could happen quickly — sometimes within a couple of months. Huang’s doctor mailed him some Ozempic pens, which he would use to inject himself with this groundbreaking drug once a week. He started on a low dose, which was then slowly increased. In the past, Huang had experienced almost every side effect under the sun from his medications. But you know what? With Ozempic, he experienced no side effects at all.

I have felt the muscle pull away from the bone. For a time I was mislead into thinking that I avenge these acts of harm against me. I realized that by living and growing stronger on a diet of scar tissue, I had something better than revenge. I have the best of your bad situation. I am like the roach, the rock, the mountain. I will not die. I will not break. I will not move. Face it. You’ll go to your grave knowing you never had what it took to stop me.

The first solution, according to Dr. David Sinclair and other top scientists in the age reversal space, lies in NAD+ supplements. Sinclair’s supplement of choice is nicotinamide mononucleotide (NMN).

Master: It is Love. Love is the medicine that accelerates the process of healing. There is no other medicine but unconditional love. Not: I love you if, or I love myself if. There is no if. There is no justification. There is no explanation. It is just to love. Love yourself, love your neighbor, and love your enemies. This is simple, common sense, but we cannot love others until we love ourselves. That is why we must begin with self-love.

Omega-3 optimizer: SmartPrime-Om: With his partners, Dr. Lopez has leveraged artificial intelligence to identify a cocktail of methylation pathway nutrients and plant-based bioactive ingredients found in sesame seed oil extract that can expand the benefits of fish oil and increase activity of genes and enzymes responsible for increasing the body’s “pool” of omega-3s like DHA, DPA, and EPA. SmartPrime-Om also promotes delivery of omega-3s in the ideal biochemical phospholipid package to increase benefits for most cells, tissues, and major organs. 8. 23Vitals for nutraceutical immune optimization was formulated to shore up our bodies on a molecular level and rejuvenate our immune system. It contains 23 bioactive ingredients, covering more than fifty human clinical trials showing immune system bolstering, and other ingredients to support our digestive tract, respiratory, and cardiovascular health, and muscle and joint recovery from exercise stress. It’s designed to promote a healthy immune response when we need to fight off a challenge, and then tone down inflammation once the threat has been neutralized and the “wave” has receded. Available in a ready-to-mix powder. I use this personally, and am also an investor in the company.

Phase 3: Forgiveness As I shared in Chapter 7, forgiveness is critical to Blissipline and the peak states needed for extraordinary living. Here you’ll incorporate the forgiveness exercise from that chapter into your daily practice. Science is now showing that forgiveness can lead to profound health benefits, including reduced back pain, higher athletic performance, better heart health, and greater feelings of happiness. One study of a small group of people with chronic back pain showed that those who meditated with a focus on moving from anger to compassion reported less pain and anxiety compared to those who got regular care. Another study found that forgiving someone improved blood pressure and reduced the workload on the heart. Interesting that lightening the heart of negativity should literally help it. Research on the impact of forgiveness by Xue Zheng of Erasmus University’s Rotterdam School of Management showed that forgiveness makes the body seemingly stronger. “Our research shows that forgivers perceive a less daunting world and perform better on challenging physical tasks,” said Zheng. In one study, participants could actually jump higher after writing an account of forgiving someone who had harmed them. In another study by Zheng, participants who were asked to guess at the steepness of a hill described the hill as less steep after they had written down an account of an incident where they had forgiven someone. In a previous chapter, I described my own powerful experiences with forgiveness during meditation. That’s why forgiveness is one of the components of the Six-Phase — it strengthens not only your body, but also your soul.

Here is the roadmap for the chapter ahead. We’ll be diving into what we consider the five key therapeutic areas that you can focus on, today, to increase your energy and vitality: 1. Peptides 2. Metformin 3. Hormone optimization therapy (HOT) 4. NAD+ precursors 5. Key nutraceuticals

Hace algunos años, Biosplice publicó un estudio de su tratamiento para la osteoartritis, una enfermedad dolorosa y debilitante que afecta a 30 millones de personas solo en los Estados Unidos. De 61 pacientes que recibieron una sola inyección en la rodilla, los 61 mostraron una mejoría visible (menos dolor, más movilidad) veinticuatro semanas después. Aún más notable, agregaron en promedio casi dos milímetros de cartílago fresco.

Sinclair’s supplement of choice is nicotinamide mononucleotide (NMN).

AN NAD+ BOOSTER BEING TESTED BY THE US SPECIAL FORCES When it comes to boosting NAD+, there may be a new game in town in the next two or three years and it goes by the code name MIB-626. MIB-626 is a proprietary, synthetically manufactured molecule that is similar to, but not identical to NMN. It’s being developed and tested by a company called Metrobiotech that Peter and I have invested in. Historically, when measured, the most NMN has been able to boost NAD+ levels intracellularly has been 40 percent, but recent studies in humans show that fourteen days of dosing with MIB-626 can raise NAD+ levels by as much as 200 to 300 percent! “We’ve discovered a way to reverse vascular aging by boosting the presence of naturally occurring molecules in the body that augment the physiological response to exercise,” said senior study investigator David Sinclair.

Someday this pain will be useful to you