Sinclair’s supplement of choice is nicotinamide mononucleotide (NMN).

AN NAD+ BOOSTER BEING TESTED BY THE US SPECIAL FORCES When it comes to boosting NAD+, there may be a new game in town in the next two or three years and it goes by the code name MIB-626. MIB-626 is a proprietary, synthetically manufactured molecule that is similar to, but not identical to NMN. It’s being developed and tested by a company called Metrobiotech that Peter and I have invested in. Historically, when measured, the most NMN has been able to boost NAD+ levels intracellularly has been 40 percent, but recent studies in humans show that fourteen days of dosing with MIB-626 can raise NAD+ levels by as much as 200 to 300 percent! “We’ve discovered a way to reverse vascular aging by boosting the presence of naturally occurring molecules in the body that augment the physiological response to exercise,” said senior study investigator David Sinclair.

THERAPEUTIC #2: METFORMIN — THE LOW-RISK WONDER DRUG “Metformin may have already saved more people from cancer deaths than any drug in history.”12 — LEWIS CANTLEY, director of the Meyer Cancer Center at Weill Cornell Medical College Now let’s take a look at another amazing medicine, one that our friend Dr. David Sinclair and millions of other people utilize every day… metformin. The FDA-approved, first-line treatment for type 2 diabetes, metformin, is wildly popular in the longevity field. My coauthors Bob Hariri and Peter Diamandis have been taking it for years. So have futurist-par-excellence Ray Kurzweil and biotech entrepreneur Ned David. And so does Nobel Prize winner James Watson of double-helix fame, who once went so far as to say that metformin might be “our only real clue into the business” of beating cancer. When a recent anti-aging forum of 300 people was asked who was using this medicine to extend their healthspan, half the audience raised their hands. As David Sinclair says, metformin “might work on aging itself.”13

Vitamin D3 boasts a strong safety profile, along with broad and deep evidence that links it to brain, metabolic, cardiovascular, muscle, bone, lung, and immune health. New and emerging research suggests that vitamin D supplements may also slow down our epigenetic/biological aging.29, 30 2. Omega-3 fish oil: Over the last thirty years or so, the typical Western diet has added more and more pro-inflammatory omega-6 polyunsaturated fatty acids versus anti-inflammatory omega-3 PUFAs. Over the same period, we’ve seen an associated rise in chronic inflammatory diseases, including obesity, cardiovascular disease, rheumatoid arthritis, and Alzheimer’s disease. 31 Rich in omega-3s, fish oil is another incredibly versatile nutraceutical tool with multi-pronged benefits from head to toe. By restoring a healthier PUFA ratio, it especially helps your brain and heart. Regular consumption of fatty fish like salmon has been linked to a lower risk of congestive heart failure, coronary heart disease, sudden cardiac death, and stroke.32 In an observational study, omega-3 fish oil supplementation was also associated with a slower biological clock.33 3. Magnesium deficiency affects more than 45 percent of the U.S. population. Supplements can help us maintain brain and cardiovascular health, normal blood pressure, and healthy blood sugar metabolism. They may also reduce inflammation and help activate our vitamin D. 4. Vitamin K1/K2 supports blood clotting, heart/ blood vessel health, and bone health.34 5. Choline supplements with brain bioavailability, such as CDP-Choline, citicoline, or alpha-GPC, can boost your body’s storehouse of the neurotransmitter acetylcholine and possibly support liver and brain function, while protecting it from age-related insults.35 6. Creatine: This one may surprise you, since it’s often associated with serious athletes and fitness buffs. But according to Dr. Lopez, it’s “a bona fide arrow in my longevity nutraceutical quiver for most individuals, and especi

STEP THREE: MAXIMIZE YOUR ENERGY & REGENERATION Consider what aspects of Vitality Pharmacy (Chapter 10) might help you accelerate your energy, your strength, your vitality. Or help you to recover from challenges you may be facing. 1. Are you going to expand your capacity by optimizing your hormones through H.O.T. (hormone optimization therapy)? 2. Would peptides be something you may want to consider? Are there any peptides that you’d like to look into that could make a difference in anything from your immune system to sexual desire and drive? 3. What are some of the pharmaceutical-grade supplements that you might want to have to start your day with energy or to get yourself to sleep at night without side effects? 4. Or would you like to tap into NAD3 or other NMN-like products to maximize your energy and vitality?

What exactly is NAD3 and how does it work? NAD3 is a patent-pending nutraceutical containing a unique Wasabi japonica extract, theacrine and copper(I)-niacin complex. Preliminary pre-clinical and human studies suggest that it turbocharges enzymes that boost the conversion of NAD+ precursors, such as NMN, to NAD+, while also suppressing the activity proteins that deplete NAD+. Dr. Lopez explains, “NAD3 co-supplementation with any NAD+ precursor (such as NMN) is like playing both on offense and defense at the same time.

There's a cure for aging that no one talks about. It's called learning.

Beauty tips. How to look younger: Don't be born so soon.

STEP TWO: REVIEW YOUR EDUCATION If you’ve read this book, congratulations! You’ve given yourself a tremendous education. But knowledge isn’t power; it’s potential power. Decide what tools do you want to access today. And what do you want to keep track of in the future? 1. Are stem cells something that you want to pursue for some aspect of your life or for someone in your family? 2. Do you want to implement Dr. Sinclair’s Four Vitality Ingredients that help reverse biological aging? Or tap into the energy force of NMN? 3. Or, are there some technologies that you’ll want to keep track of so that you have them when you need them? Perhaps the Wnt Pathway for Osteoarthritis? 4. Is there anyone in your family or people you know whom you want to share information with about what you’ve learned here in the big 6 — heart disease, diabetes/obesity, stroke, cancer, autoimmune disease, and Alzheimer’s? 5. Are you going to keep track of Gene Therapy and CRISPR and some of the transformations it’s creating? 6. Do you know anyone who has Parkinson’s or severe addiction who could feel relief from focused Ultrasound without brain surgery? Make a list of the things that you want to act on and things you want to keep track of, so that if you or anyone you know who needs help, you’ll have answers that you can share with them and that they can consider with their doctor. Just create a little checklist for yourself. The book is here. It’s the ultimate resource you can go back to as often as you need.

I'm ready to grow young again

Isn’t it delightful to forget how old we are?

You are never too old to become younger!

Live your life and forget your age.

«Qual è la vostra ricetta per conservare la giovinezza, Irene?»
«Quando non si vive ci si conserva meravigliosamente».